Chroman-2-ylmethylamino derivatives
AssigneeAmerican Home Products Corporation
InventorRichard E. Mewshaw
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Abstract
Compounds of the formula: ##STR1## in which Z is hydrogen or a halogen; n is one of the integers 1, 2, 3, or 4; m is one of the integers 0 or 1; R is a substituted or unsubstituted aryl group in which the substituents are, independently, one or two members selected from the group consisting of alkyl, hydroxy, halo or amino groups; R.sup.2 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs.
Claims20
A compound of the formula:
- ##STR8## in which Z is hydrogen or a halogen;
- n is one of the integers 1, 2, 3,or 4;
- m is one of the integers 0 or 1;
- R is ##STR9## R.sup.2 is hydrogen or alkyl of 1 to 3 carbon atoms;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.