Process for preparing intermediates for the synthesis of D1 antagonists
AssigneeSchering Corporation
InventorsDonald Hou, Richard W. Draper, Gary M. Lee, Janet L. Mas
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Abstract
Disclosed are a process and intermediates of the formulae ##STR1## wherein X.sup.- is halide, BF.sub.4.sup.-, R.sup.3 SO.sub.3.sup.-, wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl, CF.sub.3, C.sub.1 -C.sub.6 alkylphenyl or phenyl, and Q is a group of the formula ##STR2## wherein R is C.sub.1 -C.sub.6 alkyl; useful for preparing benzazepine intermediates of the formula ##STR3## These benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.
Claims3
A compound of the formula ##STR60## wherein Q is a group of the formula ##STR61## wherein R is C.sub.1 -C.sub.6 alkyl.
A chiral compound of the formula ##STR63## wherein R.sup.1 is H or CH.sub.3 ;
- and Q is a group of the formula ##STR64## wherein R is C.sub.1 -C.sub.6 alkyl.
Dependencies are inferred from the claim text.