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US 5,670,661 AGranted
Process for producing lactones and lactones obtained with this process
AssigneeIndustrie Chimiche Caffaro, S.p.A.
InventorsLivius Cotarca, Roberto Bianchini
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Abstract
The present invention relates to a process for producing lactones starting from cyclic ketones which comprises an oxidation reaction which is performed in the presence of an optionally substituted cycloaliphatic peracid or of an optionally substituted aliphatic peracid that is immiscible with water. The process allows to obtain high selectivity, does not entail the use of dangerous reagents, and allows excellent economic advantages.
Claims14
A process for preparing a compound according to formula (1):
- ##STR6## wherein each one of R.sup.1 and R.sup.3 is hydrogen, alkyl, alkyl-aryl, halogen, cyano-alkyl, carboxyl-alkyl, carbalkoxy-alkyl or hydroxy;
- and
- R.sup.2 is hydrogen, alkyl, alkyl-aryl, halogen, cyano-alkyl, carboxy-alkyl, carbalkoxyalkyl, hydroxyl, or CH.sub.2 CH.sub.2 --R.sup.4 ;
- R.sup.4 is Y or a chemical precursor of Y;
- Y is COOH, CN, CONH.sub.2 or COOR.sup.5 ;
- R.sup.5 is alkyl, aryl or substituted alkyl or aryl;
- and
- n is between 1 and 9, said process comprising the oxidation of a compound according to formula (2):
- ##STR7## wherein each of R.sup.1, R.sup.2, R.sup.3 and n have the same meaning as set forth above, said oxidation being conducted in the presence of an organic peracid selected from a cycloaliphatic peracid or substituted cycloaliphatic peracid, said peracid being substantially immiscible with water and being prepared by reoxidation of an organic acid coproduced in said oxidation.
6 more elements
A process for preparing a compound according to formula (1):
- ##STR8## wherein each one of R.sup.1 and R.sup.3 is hydrogen, alkyl, alkyl-aryl, halogen, cyano-alkyl, carboxyl-alkyl, carbalkoxy-alkyl or hydroxy;
- and
- R.sup.2 is hydrogen, alkyl, alkyl-aryl, halogen, cyano-alkyl, carboxy-alkyl, carbalkoxyalkyl, hydroxyl, or CH.sub.2 CH.sub.2 --R.sup.4 ;
- R.sup.4 is Y or a chemical precursor of Y;
- Y is COOH, CN, CONH.sub.2 or COOR.sup.5 ;
- R.sup.5 is alkyl, aryl or substituted alkyl or aryl;
- and n is between 1 and 9, said process comprising the oxidation of a compound according to formula (2):
- ##STR9## wherein each of R.sup.1, R.sup.2, R.sup.3 and n have the same meaning as set forth above, said oxidation being conducted in the presence of a peracid selected from a cycloaliphatic peracid or substituted cycloaliphatic peracid, said peracid being substantially immiscible with water and being prepared by reoxidation of an organic acid coproduced in said oxidation, said compound according to formula (2) and said peracid being included in said oxidation process in a mole ratio between 0.25 and 10.
5 more elements
Dependencies are inferred from the claim text.