Process for preparing 7-trialkylsilyl baccatin III
AssigneeRhone-Poulenc Rorer S.A.
InventorsJean-Pierre Bastart, Jean-Pierre Leconte
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Abstract
The present invention relates to a novel process for the preparation of 7-trialkylsilylbaccatin III of general formula: ##STR1## in which the symbols R, which may be identical or different, represent alkyl radicals containing 1 to 4 carbon atoms which are optionally substituted with a phenyl radical, starting with 10-deacetylbaccatin III of formula: ##STR2## In the general formula (I), each of the symbols R preferably represents a straight or branched alkyl radical containing 1 to 4 carbon atoms. Even more particularly, each of the symbols R represents an ethyl radical.
Claims10
Process for the preparation of 7-trialkylsilylbaccatin III of general formula:
- ##STR3## in which the symbols R, which may be identical or different, represent straight or branched alkyl radicals containing 1 to 4 carbon atoms which are optionally substituted with a phenyl radical, characterized in that 10-deacetylbaccatin III of formula:
- ##STR4## is treated with a silylating agent of general formula:
- Hal--Si(R).sub.3 (III)
- in which R is defined as above, then with acetic anhydride without isolating the intermediate 7-trialkylsilyl-10-deacetylbaccatin III.
Dependencies are inferred from the claim text.