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US 5,670,653 AGranted
Process for the manufacture of (4,5)-trans-oxazolidines
AssigneeHoffmann-La Roche Inc.
InventorHans Hilpert
Life of this patent
Estimating the term…
Abstract
Compounds containing a (4,5)-cis-2-oxo-oxazolidine ring are isomerized to the corresponding (4,5)-trans-2-oxo-oxazolidine by treating the cis compound with a strong base.
Claims14
A process for isomerizing a compound containing a (4,5)-cis-2-oxo-oxazolidine ring to the corresponding compound containing a (4,5)-trans-2-oxo-oxazolidine ring, comprising treating the (4,5)-cis compound with a strong base to give the (4,5)-trans compound.
A process for producing (4,5)-trans-2-oxo-oxazolidines, which process comprises treating a (4,5)-cis-2-oxo-oxazolidine of the structure:
- ##STR3## wherein R.sup.1 is benzyl or isobutyl,
- R.sup.2 is an acid protecting group;
- and
- R.sup.3 is an amino protecting group,
- with a strong base to give a (4,5)-trans-2-oxo-oxazolidine of the structure:
- ##STR4##
3 more elements
Dependencies are inferred from the claim text.