Elk ligand fusion proteins
AssigneeImmunex Corporation
InventorsStewart Lyman, M. Patricia Beckmann, Peter R. Baum
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Abstract
elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.
Claims12
A soluble human elk-L/Fc fusion protein comprising amino acids 1-213 of SEQ ID NO:2 fused to the N-terminus of an Fc polypeptide.
An elk-L/Fc fusion protein comprising a soluble elk-L polypeptide fused to an Fc polypeptide, wherein the amino acid sequence of said elk-L polypeptide is selected from the group consisting of the extracellular domain of human elk-L (amino acids 1-213 of SEQ ID NO:2), and a fragment of said extracellular domain, wherein said fragment binds elk.
An elk-L/Fc fusion protein which binds elk comprising a soluble elk-L polypeptide fused to an Fc polypeptide, wherein the soluble elk-L polypeptide comprises an amino acid sequence that is at least 80% identical to the sequence of residues 1-213 of SEQ ID NO:2.
An oligomer comprising from two to four soluble elk-L polypeptides, wherein said soluble elk-L polypeptides each comprise an amino acid sequence that is at least 80% identical to the sequence of residues 1-213 of SEQ ID NO:2, wherein said oligomer binds elk.
An oligomer comprising from two to four soluble elk-L polypeptides, wherein the amino acid sequence of each of said elk-L polypeptides is selected from the group consisting of the extracellular domain of human elk-L (amino acids 1-213 of SEQ ID NO:2), and a fragment of said extracellular domain, wherein said fragment binds elk.
Dependencies are inferred from the claim text.