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US 5,670,547 AGranted
Moisturizing vehicle for topical application of vitamin A acid
AssigneeDow Pharmaceutical Sciences, Inc.
InventorsElliott A. Milstein, Nathan Milstein
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Abstract
A formulation containing tretinoin, a gelling agent, proteinaceous material, and water is provided for the uniform topical application of tretinoin. The water-based formulation is oil- and fat-free, alcohol-free, and rich in proteinaceous material. The formulation is stable over time and is comedogenic and less irritating and drying to the skin.
Claims22
A stable aqueous gel formulation comprising:
- a) from about 0.001% to about 1% by weight tretinoin;
- b) from about 0.05% to about 15% by weight of a gelling agent for uniformly delivering said tretinoin to the surface of the skin in a way which makes it readily absorbable;
- c) from about 0.001% to about 50% by weight of a proteinaceous material, wherein said proteinaceous material comprises a protein, polypeptide, amino acid, mucopolysaccharide, or a mixture thereof, wherein said proteinaceous material is in sufficient quantity to stabilize said gelling agent and tretinoin formulation;
- and
- d) water;
- wherein said formulation is free of fat and oil and substantially free of alcohol as a carrier for the tretinoin, said weight percentages being based on 100 weight percent of the formulation, and wherein said formulation is a stable aqueous gel.
3 more elements
A stable aqueous gel formulation comprising:
- a) from about 0.001% to about 1% by weight tretinoin;
- b) from about 0.05% to about 15% by weight of an acidic carboxyl polymer gelling agent for uniformly delivering said tretinoin to the surface of the skin in a way which makes it readily absorbable;
- c) from about 0.001% to about 50% by weight of a proteinaceous material, wherein said proteinaceous material comprises a protein, polypeptide, amino acid, mucopolysaccharide, or a mixture thereof, wherein said proteinaceous material is in sufficient quantity to stabilize said acidic carboxyl polymer and tretinoin formulation;
- and
- d) water;
- wherein the pH of said formulation is between approximately 5.2 and approximately 5.5 and wherein said formulation is free of fat and oil and substantially free of alcohol as a carrier for the tretinoin, said weight percentages being based on 100 weight percent of the formulation, and wherein said formulation is a stable aqueous gel.
3 more elements
Dependencies are inferred from the claim text.