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US 5,670,546 AGranted
N-Arylalkylphenylacetamide derivatives
AssigneeKorean Research Institute of Chemical Technology
InventorsNo-Sang Park, Young-Sik Jung, Churl-Min Seong, Jong-Cheol Lee, Jin-Il Choi, Seung-Won Choi, Yeon-Joo Choi, Kwang-Sook Lee
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Abstract
N-arylalkylphenylacetamide compounds of formula (I), and pharmaceutically acceptable salts thereof, possess potent analgesic and anti-inflammatory activities. ##STR1##
Claims4
A N-arylalkylphenylacetamide compound of formula (I) and pharmaceutically acceptable salts thereof:
- ##STR7## wherein:
- X is hydroxy or methoxy;
- Y is hydroxy;
- or NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2, which may be the same or different, are independently hydrogen, C.sub.1-3 alkyl, C.sub.1-3 hydroxyalkyl, C.sub.1-3 aminoalkyl, formyl, C.sub.1-3 alkylcarbonyl, C.sub.1-3 alkoxycarbonyl, arylalkoxycarbonyl, aryl, or aroyl, with the proviso that both R.sup.1 and R.sup.2 are not simultaneously hydrogen, or R.sup.1 and R.sup.2 may form a heterocyclic ring containing one or more heteroatoms together with the nitrogen atom to which they are attached;
- Z, which may be the same or different when p is greater than 1, is hydrogen, halogen, methylenedioxy, trifluoromethyl, or C.sub.1-5 alkyl;
- n is an integer ranging from 2 to 4;
- and
- p is an integer ranging from 1 to 5.
5 more elements
Dependencies are inferred from the claim text.