Substituted benzoylguanidines process for their preparation their use as a medicament or diagnostic and medicament containing them

Abstract

There are described benzoylguanidines of the formula I ##STR1## where R(1) is hydrogen, Hal, --NO.sub.2, --CN, --CF.sub.3, R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 --, where m is zero to 2, R(4) and R(5) are alk(en)yl or --C.sub.n H.sub.2n --R(7), n is zero to 4, where R(5) also has the meaning of H, R(6) is H or (C.sub.1 -C.sub.4)-alkyl, where R(5) and R(6) together can be 4 or 5 methylene groups, R(2) is --SR(10), --OR(10), --NRH(10), --NR(10)R(11), --CHR(10)R(12), ##STR2## where R(10) and R(11) are identical or different and are --›CHR(16)!.sub.s --(CH.sub.2).sub.p --(CHOH).sub.q --(CH.sub.2).sub.r --(CH.sub.2 OH).sub.t --R(21) or --(CH.sub.2).sub.p --O--(CH.sub.2 --CH.sub.2 O).sub.q --R(21) R(12) and R(13) are hydrogen or alkyl or, together with the carbon atom carrying them, form a cycloalkyl, R(14) is H, (cyclo)alkyl or --C.sub.n H.sub.2n --R(15), R(3) is defined as R(1), or is alkyl, hydrogen or --X--R(22) where X is oxygen, S or NR(16), and their pharmaceutically tolerable salts. The compounds I have very good antiarrhythmic properties, but not undesired salidiuretic properties. Moreover, they are distinguished by strong inhibitory action on the proliferation of cells.

Dependencies are inferred from the claim text.