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US 5,670,535 AGranted
Thiophene compounds
AssigneeAdir et Compagnie
InventorsMichel Wierzbicki, Marie-Fran.cedilla.oise Boussard, Jacqueline Bonnet, Massimo Sabatini, Philippe Pastoureau
Life of this patent
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Abstract
The invention provides new compounds pertaining to the class of: 2-(aminocarbonylalkylcarbonyl)-5-phenylalkyllthiophene, enantiomers and physiologically tolerable salts thereof. For example: 5-4-(4-methylphenyl)butyl-2-{3,3-dimethyl-4-N'-(2,3,4-trimethoxybenzyl)-N -piperazinylcarbonyl!butyryl}thiophene is described. Medicinal products containing the same are useful in the treatment of any pathology involving bone hyper-resorption.
Claims9
A thiophene compound selected from those of formula I:
- ##STR8## in which:
- each of X and Y, which are the same or different, are selected from the group consisting of hydrogen, halogen, alkyl and alkoxy each having 1 to 5 carbon atoms inclusive in straight or branched chains, and dialkylamino in which each alkyl contains 1 to 5 carbon atoms inclusive in straight or branched chains;
- n is selected from integers 2 to 5 inclusive;
- m is selected from zero, one and two;
- R is selected from the group consisting of hydrogen and alkyl having from 1 to 5 carbon atoms inclusive in straight or branched chains;
- and
- R' is selected from the group consisting of alkyl having from 1 to 5 carbon atoms inclusive in straight or branched chains, or alternatively
- R and R' together with the nitrogen to which they are bonded (viz the group ##STR9## as a whole is selected from the group consisting of:
- unsubstituted pentagonal and hexagonal heterocycles each selected from those containing one nitrogen, one nitrogen and one oxygen, and two nitrogen, and these heterocycles substituted by a substituent selected from the group consisting of:
- straight or branched (C.sub.1 -C.sub.5) alkyl and unsubstituted, mono- and poly- substituted arylalkyl in which the alkyl moiety contains 1 to 5 carbon atoms inclusive in straight or branched chains, and the substituent(s) on the aryl moiety is selected from the group consisting of:
- halogen, straight and branched (C.sub.1 -C.sub.5) alkyl, and straight and branched (C.sub.1 -C.sub.5) alkoxy;
- and,
- the corresponding enantiomers, and
- their addition salts with physiologically-tolerable acids.
11 more elements
Dependencies are inferred from the claim text.