Amino acid derivatives, the process for their preparation and their applications to therapy
AssigneeSociete Civile Bioprojet
InventorsJean-Christophe Plaquevent, Denis Danvy, Thierry Monteil, Helene Greciet, Lucette Duhamel, Pierre Duhamel, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte
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Abstract
Amino acid derivatives having both enkephalinase and ACE inhibiting properties corresponding to the formula: ##STR1##
Claims4
Amino acid derivative corresponding to the general formulae ##STR53## wherein ##STR54## wherein Z and Y are O and n=1 or 2 R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkylene group, a phenyl group, a lower phenylalkylene group, a lower hydroxyphenylalkylene group, a lower aminoalkylene group, a lower guanidinoalkylene group, a lower mercaptoalkylene group, a lower alkylthio lower alkylene group, a lower imidazolylalkylene group, a lower indolylalkylene group, a lower carbamylalkylene group, a lower carboxylalkylene group or one of the following groups:
- ##STR55## wherein Z', Y' and n have the meanings defined below:
- ______________________________________ Z' Y' n ______________________________________ 0 0 1 0 0 2 0 CH.sub.2 1 CH.sub.2 CH.sub.2 1 CH.sub.2 CH.sub.2 2 ______________________________________
- wherein R.sub.4 represents a linear or branched alkyl group, a phenyl group or a phenylalkyl group, and wherein R.sub.5 represents a linear or branched aliphatic acyl radical, or an aromatic acyl radical.
Dependencies are inferred from the claim text.