Substituted 4-phenyl-6-amino-nicotinic acid compounds useful in the treatment of CNS disorders
AssigneeBayer Aktiengesellschaft
InventorsKlaus Urbahns, Siegfried Goldmann, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie Viktor De Vry
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Abstract
The application relates to substituted 4-phenyl-6-amino-nicotinic acid derivatives for therapeutic use, to novel active compounds and to their use as cerebrally active agents. The active compounds are prepared by oxidizing appropriately substituted dihydropyridines according to customary methods.
Claims13
A method of treating diseases which are affected by modulating the calcium-dependent potassium channel which comprises administering to a patient in need thereof an effective amount of a 4-phenyl-6-amino-dihydropyridine of the formula ##STR26## in which A represents aryl having 6 to 10 carbon atoms or pyridyl, each of which is optionally substituted up to 3 times by identical or different substituents selected from the group consisting of nitro, cyano, phenyl, halogen and trifluoromethyl or by straight-chain or branched alkylthio or alkoxy in each case having up to 6 carbon atoms,
- D represents cyano or nitro,
- R.sup.1 represents hydrogen or straight-chain or branched alkyl having up to 8 carbon atoms,
- R.sup.2 and R.sup.3 are identical or different and represent hydrogen or straight-chain or branched alkyl or acyl in each case having up to 6 carbon atoms,
- or a salt thereof.
A 4-phenyl-6-amino-nicotinic acid compound of the formula ##STR27## in which A represents aryl having 6 to 10 carbon atoms or pyridyl, each of which is optionally substituted up to 3 times by identical or different substituents selected from the group consisting of nitro, cyano, phenyl, halogen and trifluoromethyl or by straight-chain or branched alkylthio or alkoxy in each case having up to 6 carbon atoms,
- D represents cyano or nitro,
- R.sup.1 represents hydrogen or straight-chain or branched alkyl having up to 8 carbon atoms,
- R.sup.2 and R.sup.3 are identical or different and represent hydrogen or straight-chain or branched alkyl or acyl in each case having up to 6 carbon atoms
- or a salt thereof, where
- ethyl 6-amino-5-cyano-2-methyl-4-phenyl-nicotinate,
- ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-nicotinoate,
- ethyl 6-amino-5-cyano-2-methyl-4-(4-methoxyphenyl)-nicotinoate and
- ethyl 6-amino-5-cyano-2-methyl-4-(4-nitrophenyl)-nicotinoate
- are excluded.
Dependencies are inferred from the claim text.