Method for inhibiting virus replication in mammalian cells using carbostyil derivatives
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsErwin W. Gelfand, Naohiro Terada
Life of this patent
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Abstract
A method for inhibiting nucleoside and nucleobase transport in mammalian cells, as well as to a method for inhibition of virus replication, and augmenting phosphorylation of nucleoside analogues, are disclosed, wherein each method uses, as the active agent, a carbostyril derivative.
Claims22
A method for inhibiting DNA virus replication, comprising exposing cells which have been infected with said DNA virus to a pharmaceutically effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR3## wherein R is a benzoyl group which may optionally have lower alkoxy groups on the phenyl ring as substituents and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
A method for treating Epstein-Barr virus infection, comprising administering to a subject in need of such treatment, a pharmaceutically effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR4## wherein R is a benzoyl group which may optionally have lower alkoxy groups on the phenyl ring as substituents and the carbon--carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
A method for treating cytomegalovirus infection, comprising administering to a subject in need of such treatment, a pharmaceutically effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR5## wherein R is a benzoyl group which may optionally have lower alkoxy groups on the phenyl ring as substituents and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
A method for inhibiting RNA virus replication, comprising exposing cells which have been infected with said RNA virus to a pharmaceutically effective amount of an anti-RNA virus compound and a pharmaceutically effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR6## wherein R is a benzoyl group which may optionally have lower alkoxy groups on the phenyl ring as substituents and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
A method for treating HIV virus infection, comprising administering to a subject in need of such treatment, a pharmaceutically effective amount of an anti-HIV virus compound and a pharmaceutically effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR7## wherein R is a benzoyl group which may optionally have lower alkoxy groups on the phenyl ring as substituents and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
A method for augmenting phosphorylation on a nucleoside analogue comprising co-administering to cells, said nucleoside analogue and a pharmaceutically effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR8## wherein R is a benzoyl group which may optionally have lower alkoxy groups on the phenyl ring as substituents and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
Dependencies are inferred from the claim text.