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US 5,670,511 AGranted
Indolepiperidine derivatives
AssigneeMerck Patent GmbH
InventorsJoachim Marz, Hartmut Greiner, Christoph Seyfried, Gerd Bartoszyk
Life of this patent
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Abstract
Indolepiperidine derivatives of the formula I ##STR1## and their physiologically acceptable salts exhibit action on the central nervous system, in particular dopamine-agonistic or dopamine-antagonistic action.
Claims17
An indolepiperidine compound of the formula I ##STR7## in which R.sup.1 is H, A, OH, OA, F, Cl, Br, I, CF.sub.3, OCF.sub.3, CN, COOH, CONH.sub.2, CONHA, CONA.sub.2 or COOA,
- R.sup.2 is --NH--CO--Ar, --NH--SO.sub.2 --Ar or D,
- Q is --C.sub.m H.sub.2m -- or --O--C.sub.n H.sub.2n --
- D is ##STR8## X.sup.1, X.sup.2 and X.sup.3 and also
- X.sup.1', X.sup.2' and X.sup.3' are in each case independently of one another N or CH, where the respective H atoms can also be replaced by a substituent selected from the group consisting of A, OA, F, Cl, Br, I, CF.sub.3, OCF.sub.3, CN, COOH and COOA,
- Z is CO, SO.sub.2 or SO,
- A is alkyl having 1 to 6 C atoms,
- Ar is 1-naphthyl which is unsubstituted or mono- or disubstituted by A, OA, F, Cl, Br, I, CF.sub.3, CN, COOH or COOA, where one, two, three or four CH groups in the ring are optionally replaced by N
- m is 1, 2, 3 or 4 and
- n is 1, 2 or 3,
- and physiologically acceptable salts thereof.
7 more elements
Dependencies are inferred from the claim text.