Pyridyl substituted spirodienes for the treatment of inflammation
AssigneeG. D. Searle & Co.
InventorsHorng-Chih Huang, David R. Reitz
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Abstract
A class of substituted spirodienes is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein A is selected from ##STR2## wherein each of R.sup.1 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl; alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl, haloalkylsulfonyl, and sulfamyl; and wherein n is a number selected from 0, 1, 2 and 3; or a pharmaceutically-acceptable salt thereof.
Claims22
A compound of Formula I ##STR32## wherein A is selected from ##STR33## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido;
- wherein R.sup.3 is methylsulfonyl or sulfamyl;
- wherein each of R.sup.6 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, mercapto, alkylsulfonyl, haloalkylsulfonyl and sulfamyl;
- and wherein n is a number selected from 0, 1, 2 and 3;
- or a pharmaceutically-acceptable salt thereof.
A compound of Formula IV ##STR34## wherein n is a number selected from 0, 1, 2 and 3;
- wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido;
- wherein R.sup.3 is methylsulfonyl or sulfamyl;
- and wherein each of R.sup.7 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, and mercapto;
- or a pharmaceutically-acceptable salt thereof.
A compound of Formula V ##STR35## wherein n is a number selected from 0, 1, 2 and 3;
- wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido;
- wherein R.sup.3 is methylsulfonyl or sulfamyl;
- and wherein each of R.sup.6 and R.sup.8 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, and mercapto;
- or a pharmaceutically-acceptable salt thereof.
A compound of Formula VI ##STR36## wherein n is a number selected from 0, 1, 2 and 3;
- wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido;
- wherein R.sup.3 is methylsulfonyl or sulfamyl;
- and wherein each of R.sup.6, R.sup.7, R.sup.9 and R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, and mercapto;
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.