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US 5,670,505 AGranted
Piperazine derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsMasaaki Matsuo, Daijiro Hagiwara, Takashi Manabe, Nobukiyo Konishi, Shinji Shigenaga, Kenji Murano, Hiroshi Matsuda, Hiroshi Miyake
Life of this patent
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Abstract
A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl; Y is a direct bond or lower alkylene; and R.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.
Claims8
A compound of the formula:
- ##STR107## wherein:
- X is carbonyl;
- Y is lower alkylene;
- R.sup.1 is halo (lower alkyl);
- R.sup.2 is indolyl;
- R.sup.3 is hydrogen;
- R.sup.4 is a group of the formula --A--(Z).sub.p, in which A is a direct bond or lower alkylene, wherein Z is benzoyl which is substituted by lower alkanoyl or lower alkansulfonylamino;
- or a carbamoyl derivative having the formula:
- ##STR108## wherein R.sup.4.sub.d is hydrogen and R.sup.4.sub.e is hydrogen or 1-piperazinyl substituted by lower alkyl;
- or
- R.sup.4.sub.d and R.sup.4e together with the nitrogen atom form 1-piperazinyl substituted by cyclo (lower) alkyl, 1-piperidyl substituted by piperidyl or 1-homopiperazinyl substituted by lower alkyl;
- P is 1;
- and
- n is 2;
- or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.