Method of pretreating an animal with a corticosteroid prior to infusion of a perfluorochemical emulsion
AssigneeHemaGen/PFC
InventorsThomas H. Goodin, Robert J. Kaufman
Life of this patent
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Abstract
This invention is directed to a method of attenuating or preventing the adverse side-effects of a perfluorochemical (PFC) emulsion on the hemostatic system and serum chemistry of an animal. The method includes intravenously administering a corticosteroid to an animal prior to intravenous administration of a PFC emulsion, in an amount sufficient to improve the adverse effects of the PFC upon the hemostatic system and serum triglyceride/enzyme levels of the animal. After administration of the corticosteroid, the PFC emulsion is administered intravenously. Preferably, the corticosteroid is dexamethasone, and the PFC is perfluorodichlorooctane.
Claims10
A method of improving the adverse effects of a perfluorochemical emulsion on the hemostatic system of a primate, comprising the steps of:
- intravenously administering a corticosteroid to a primate prior to intravenous administration of a perfluorochemical emulsion including a perfluorochemical, said corticosteroid administered at a dose of from about 0.2 mgg of body weight to about 6 mg/kg of body weight to improve the adverse effects of said perfluorochemical which occur at least about one day or more post administration of said perfluorochemical upon the hemostatic system of said primate;
- and
- subsequently intravenously administering said perfluorochemical emulsion.
Dependencies are inferred from the claim text.