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US 5,670,492 AGranted
DC-89 derivatives
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsNobuyoshi Amishiro, Satoru Nagamura, Hiromitsu Saito, Eiji Kobayashi, Akihiko Okamoto, Katsushige Gomi
Life of this patent
Estimating the term…
Abstract
Provided are DC-89 derivatives represented by the formula: ##STR1## wherein X represents Cl or Br, R represents hydrogen or COR.sup.1, and W represents ##STR2## and pharmaceutically acceptable salts thereof. The compounds of the present invention have excellent anti-tumor activity and are useful as anti-tumor agents.
Claims3
A DC-89 derivative represented by the formula:
- ##STR155## in which X represents Cl or Br, R reprsents hydrogen or COR.sup.1 in which R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl (wherein the substituted lower alkyl is substituted with 1 to 3 moieties selected from the group consisting of lower alkoxy, lower alkylthio optionally substituted with carboxy, carboxy, lower alkoxycarbonyl, amino, mono- or di(lower alkyl)amino, cyclic amino optionally substituted with lower alkyl or cyclic amino, halogen and phenyl), substituted or unsubstituted C.sub.6-10 nonheterocyclic aryl, substituted or unsubstituted heterocyclic group selected from the group consisting of pyridyl, pyrazinyl and pyrimidinyl (wherein the substituted aryl and substituted heterocyclic group are substituted with 1 to 3 moieties independently selected from the group consisting of substituted or unsubstituted lower alkyl, lower alkoxy, lower alkoxycarbonyl, amino, mono- or di(lower alkyl)amino and halogen), NR.sup.2 R.sup.3 (in which R.sup.2 and R.sup.3 independently represent hydrogen or substituted or unsubstituted lower alkyl, amino, or mono- or di(lower alkyl) amino), ##STR156## (in which R.sup.4 represents oxygen, N--R.sup.5 (in which R.sup.5 represents hydrogen or lower alkyl), CH.sub.2 or ##STR157## or OR.sup.6 (in which R.sup.6 represents substituted or unsubstituted lower alkyl, or substituted or unsubstituted C.sub.6-10 nonheterocyclic aryl);
- and W represents ##STR158## O(CH.sub.2).sub.n CO.sub.2 R.sup.7 in which Y.sup.1, Y.sup.2 and Y.sup.3 independently represent CH or N, Q.sup.1 and Q.sup.2 independently represent hydrogen, OR.sup.7 (in which R.sup.7 represents hydrogen or substituted or unsubstituted lower alkyl), NR.sup.2 R.sup.3, NECO.sub.2 R.sup.6, or O(CH.sub.2).sub.n R.sup.8 in which n represents an integer of 1 to 4, and R.sup.8 represents CO.sub.2 R.sup.7, N.sub.3, or NR.sup.2 R.sup.3, provided that when Y.sup.1, Y.sup.2 and Y.sup.3 are CH, at least one of Q.sup.1 and Q.sup.2 is a group other than hydrogen or alkoxy, or ##STR159## (in which Y.sup.4 represents oxygen, sulfur or NH, or a pharmaceutically acceptable salt thereof.
A DC-89 derivative represented by the formula:
- ##STR160## wherein X represents Cl or Br, R represents COR.sup.1 in which R.sup.1 represents substituted or unsubstituted lower alkyl (wherein the substituted lower alkyl is substituted with 1 to 3 moieties selected from the group consisting of lower alkoxy, lower alkylthio optionally substituted with carboxy, carboxy, lower alkoxycarbonyl, amino, mono- or di(lower alkyl)amino, cyclic amino optionally substituted with lower alkyl or cyclic amino, halogen and phenyl), NR.sup.2 R.sup.3 (in which R.sup.2 and R.sup.3 independently represent substituted or unsubstituted lower alkyl or amino) or ##STR161## (in which R.sup.5 represents lower alkyl);
- and W represents ##STR162## or a pharmaceutically acceptable salt thereof.
A DC-89 derivative represented by the formula:
- ##STR163## wherein X represents Br, R.sup.5 represents lower alkyl;
- and W represents ##STR164## or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.