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US 5,670,491 AGranted
Chelate complexes and processes for their preparation
AssigneeCiba-Geigy Corporation
InventorsHans Georg Capraro, Marcus Baumann
Life of this patent
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Abstract
Phthalocyanine chelate complexes of formula I ##STR1## are described which contain as central atom M aluminum; gallium, indium, tin, ruthenium or preferably germanium and in which the remaining symbols are as defined in claim 1. The complexes can be used inter alia in the photodynamic chemotherapy of tumors.
Claims16
A compound of formula I ##STR6## wherein M is an element of main group III or IV or the Periodic Table having an atomic number of from 31 to 50 inclusive, aluminum or ruthenium,
- R.sub.1 is a radical of formula II ##STR7## wherein m is 0 or 1,
- n is an integer from 0 to 200 inclusive,
- R.sub.5 and R.sub.6 are each independently of the other lower alkyl or unsubstituted or substituted phenyl, and
- R.sub.7 is alkylthio having 1 to 20 carbon atoms, alkanoyloxy having 1 to 20 carbon atoms, unsubstituted aliphatic hydrocarbyloxy having 1 to 24 carbon atoms, or, when m is 1 and n is 0, aliphatic hydrocaryl having from 12 to 24 carbon atoms, or
- R.sub.1 is a radical of formula III ##STR8## wherein X is a bivalent aliphatic hydrocarbon radical having 1 to 23 carbon atoms,
- Y is oxygen or the group --NH--,
- R.sub.8 is aliphatic hydrocarbyl having 1 to 24 carbon atoms or unsubstituted aliphatic hydrocarbyl having 1 to 24 carbon atoms in the aliphatic moiety, and
- R.sub.5, R.sub.6 and m are as defined above,
- R.sub.2 has the same definition as R.sub.1 when M is an element of main group IV, or R.sub.2 is absent when M is an element of main group III or ruthenium,
- R.sub.3 is hydrogen, lower alkyl, lower alkylthio, unsubstituted or lower alkoxy-substituted alkoxy having 1 to 20 carbon atoms, tri-lower alkylsilyl or halogen, and
- R.sub.4 is hydrogen, lower alkyl, lower alkylthio, unsubstituted or lower alkoxy-substituted alkoxy having 1 to 20 carbon atoms, tri-lower alkylsilyl or halogen.
8 more elements
Dependencies are inferred from the claim text.