Dorsal tissue affecting factor (noggin) and compositions comprising same
AssigneeThe Regents of the University of California
InventorsRichard M. Harland, William C. Smith
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Abstract
A novel and soluble polypeptide that is highly conserved among vertebrates has been discovered, which is designated "noggin." The properties of noggin include dorsal growth inducing activity. Noggin and activin act synergistically to produce dorsal mesoderm. Noggin's cDNA has been cloned. Several expression systems have been successfully used to express biologically active noggin. Amino acid sequences representing completely conserved portions as between frog noggin and mouse noggin are: QMWLWSQTFCPVLY (SEQ ID NO:3); RFWPRYVKVGSC (SEQ ID NO:4); SKRSCSVPEGMVCK (SEQ ID NO:5); LRWRCQRR (SEQ ID NO:6); and, ISECKCSC (SEQ ID NO:7).
Claims6
A substantially pure polypeptide characterized by a physiologically active, soluble form and comprising an amino acid sequence identical to that encoded by the DNA of SEQ ID NO:1, said polypeptide having neurotrophic activity.
Dependencies are inferred from the claim text.