Pharmaceutical containing N-methylated cyclic undecapeptides
AssigneeGalena AS
InventorsMilan Stuchlik, Zdenek Pavelek, Lubos Markovic
Life of this patent
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Abstract
Medical preparations (drugs) containing N-methylated cyclic undecapeptides, especially for internal use, characterized by the presence of 0.1 to 20 weight parts of compounds from the group of cyclosporins (A), 0.3 to 60 weight parts of emulsifier (B) containing anhydromanitol oleylether and/or lactoglyceride and/or citrogylceride, 0.1 to 10 weight parts of emulsion stabilizer (C) containing aluminium-magnesium hydroxy-stearate as a lipogel and 0.2 to 40 weight parts of a solvent (D) composed of 1,4: 3,6-dianhydro-2,5-di-O-methyl-D-glucitole and/or 1,3-dimethyl-2-imidazolidone and/or ethanol, with the ratio A:B being equal to 1:05-1:30.
Claims6
Pharmaceutical preparations with N-methylated cyclic undecapeptides characterized by the following composition:
- 0.1 to 20 weight parts of compounds /A/ from a group of cyclosporines, 0.3 to 60 weight parts of emulsifiers /B/ containing anhydromannitol oleylether and/or lactoglycerides and/or citroglyceride, 0.1 to 10 weight parts of emulsion stabilizer /C/ having aluminum-magnesium hydroxystearate of empirical formula Al.sub.5 Mg.sub.10 (OH).sub.31.(C.sub.17 H.sub.35 COO).sub.4 in a form of lipogel, and 0.2 to 40 weight parts of solvent /D/ containing 1,4:3,6-dianhydro-2,5-di-O-methyl -D-glucitole and/or 1,3,-dimethyl-2-imidazolidinone, wherein the ratio A:B equals 1:0.5 to 1:30.
Dependencies are inferred from the claim text.