Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
AssigneesJoseph F. Poduslo, Geoffrey L. Curran
InventorsJoseph F. Poduslo, Geoffrey L. Curran
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Abstract
A method is provided to enhance the ability of a neurologically active compound to penetrate the blood nerve barrier (BNB) or blood brain barrier (BBB), by administration of a conjugate comprising the neurologically active compound linked to a carrier molecule that has been shown to have a substantial permeability coefficient across the BNB and BBB.
Claims21
A method to enhance the ability of a neurologically active compound to penetrate the blood-nerve-barrier or blood-brain-barrier comprising parenterally administering to a mammal in need of treatment with said neurologically active compound, a conjugate consisting of an effective amount of said neurologically active compound linked to a polyamine having a substantial permeability coefficient across the blood-nerve-barrier or blood-brain-barrier.
A pharmaceutical composition comprising a neurologically active compound linked to a polyamine in combination with a pharmaceutically acceptable carrier.
An isolated and purified composition consisting of a neurologically active compound linked to a polyamine, wherein the polyamine is present in an amount effective to increase the ability of the composition to cross the brain-nerve barrier or blood-brain barrier of a mammal to which said composition is administered.
Dependencies are inferred from the claim text.