HIV-specific ribozymes
AssigneeThe Regents of the University of California
InventorsFlossie Wong-Staal, Mang Yu, Osamu Yamada, Joshua O. Ojwang, Markley C. Leavitt, Anthony Ho
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Abstract
This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
Claims13
A retroviral vector comprising an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid sequence encoding a ribozyme which specifically cleaves a human immunodeficiency virus nucleic acid under the control of a pol III promoter.
A pol III promoter transcription cassette selected from the group of transcription cassettes present in the vectors pMJT, pMJV and pMY-2.
Dependencies are inferred from the claim text.