Methods for optimizing fluoropyrimidine cancer therapy
AssigneeUniversity of Alabama Research Foundation
InventorsMahmoud H. el Kouni, Fardos N. M. Naguib
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Abstract
The present invention provides a method of predicting whether an individual will be intolerant to the effect of fluoropyrimidines comprising the step of measuring the activity of orotate phosphoribosyltransferase activity in a biological sample obtained from said individual. Also provided is a method of determining a non-toxic dose of 5-fluoruracil in an individual in need of fluoropyrimidine therapy, comprising the step of measuring the activity of 5-fluoruracil phosphoribosyltransferase (FUPRTase) in a biological sample obtained from said individual.
Claims11
A method of predicting whether an individual will be intolerant to the effect of fluoropyrimidines comprising the step of measuring the activity of orotate phosphoribosyltransferase activity using orotate as a substrate in a biological sample obtained from said individual, wherein an increased activity of orotate phosphoribosyltransferase in the biological sample indicates that the individual will be intolerant to fluoropyrimidines.
A method of determining a non-toxic dose of 5-fluoruracil in an individual in need of fluoropyrimidine therapy, comprising the step of measuring the activity of 5-fluorouracil phosphoribosyltransferase (FUPRTase) using 5-fluorouracil as a substrate in a biological sample obtained from said individual.
Dependencies are inferred from the claim text.