Anti-tumor agent assay using PKR
AssigneesMcGill University, University of Washington
InventorsNahum Sonenberg, Michael G. Katze, Sophie Roy, Antonis E. Koromilas, Glen H. Barber
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Abstract
A method of screening human tissue for the presence of neoplastic cells, by determining the activity of PKR, P58 of anti-P58 in test cells being screened, and identifying candidate neoplastic cells on the basis of subnormal PKR, P58, or anti-P58 activity. The activities may be determined directly by measuring protein kinase activity or its equivalent, or measured indirectly, by detecting functional mutations in the various proteins. Also disclosed are assay kits for carrying out the screening method.
Claims9
A method for screening for anti-tumor agent, comprising the steps of:
- providing a system containing PKR activity;
- contacting said system with a test agent;
- measuring PKR activity before and after the addition of said agent, wherein an increase in said PKR activity is indicative of said agent being an effective anti-tumor agent.
Dependencies are inferred from the claim text.