Process for the detection of malignant melanoma
AssigneeThe Whittier Institute for Diabetes and Endocrinology
InventorsMichael Philip Nova, Ana-Maria Gonzalez, Andrew Baird
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Abstract
According to the present invention, processes for detecting the presence of neoplastic disease are provided. The processes involve the detection of a product associated with expression of genes that encode protein receptors for fibroblast growth factor in cells or a product present in a body fluid. Detection can be carried out in a variety of ways, such as by hybridization to detect the presence of mRNA or immunological assays to detect the presence of receptor protein.
Claims24
A process for detecting malignant melanoma in a subject, comprising detecting, in a sample that contains melanocytes obtained from the subject, a first product indicative of elevated expression of a fibroblast growth factor receptor gene or a second product indicative of elevated amounts of a fibroblast growth factor receptor (FGFR), wherein detection of said first or second product in elevated expression or amount, respectively, compared to a control sample containing normal or benign melanocytes indicates the presence of malignant melanoma in said subject.
A process for detecting malignant melanoma in a subject, comprising detecting, in a sample that contains melanocytes obtained from the subject, a first product indicative of elevated expression of a fibroblast growth factor receptor gene or a second product indicative of elevated amounts of a fibroblast growth factor receptor (FGFR), wherein detection of said first or second product in elevated expression or amount, respectively, compared to a control sample containing normal or benign melanocytes indicates the presence of malignant melanoma in said subject;
- and detection is effected by contacting the sample obtained from the subject with an agent that binds to the extracellular domain of an FGFR or with a nucleic acid probe that includes a sequence of at least about 20 nucleotides that hybridizes under conditions of high stringency to nucleic acid encoding the extracellular domain of an FGFR.
A process for detecting malignant melanoma in a subject, comprising detecting, in a sample that contains melanocytes obtained from the subject, a first product indicative of elevated expression of a fibroblast growth factor receptor gene or a second product indicative of elevated amounts of a fibroblast growth factor receptor (FGFR), wherein detection of said first or second product in elevated expression or amount, respectively, compared to a control sample containing normal or benign melanocytes indicates the presence of malignant melanoma in said subject;
- and detection is effected by contacting the sample obtained from said subject with an agent that binds to FGFR-1 or with a nucleic acid probe that includes a sequence of at least about 20 nucleotides that hybridizes under conditions of high stringency to nucleic acid encoding FGFR-1.
Dependencies are inferred from the claim text.