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US 5,670,314 AGranted
Genetic alterations that correlate with lung carcinomas
AssigneeThe Regents of the University of California
InventorsMichael F. Christman, Joe W. Gray, Nikki A. Levin, Pius Brzoska, Haruhiko Nakamura
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Abstract
The present invention relates to compositions and methods for detecting chromosome abnormalities correlated with lung cancer. The method contacting a nucleic acid sample from a patient with a probe which binds selectively to a target polynucleotide sequence correlated with lung cancer.
Claims14
A method of screening for the presence of small cell lung carcinoma cells in a sample, the method comprising:
- contacting a nucleic acid sample from a human patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region which is deleted in small cell lung carcinoma cells and is selected from the group consisting of 1q24, 5p, and Xq26, or a probe which binds selectively to a target polynucleotide sequence on a chromosomal region which is amplified in small cell lung carcinoma cells and is selected from the group consisting of 22q12.1-13.1, 10q26, 16p11.2, and 19p13.3;
- wherein the probe is contacted with the sample under conditions in which the probe binds selectively with the target polynucleotide sequence to form a hybridization complex;
- and
- detecting the formation of a hybridization complex.
1 more element
A method of screening for the presence of non-small cell lung carcinoma cells in a sample, the methods comprising:
- contacting a nucleic acid sample from a human patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region which is deleted in non-small cell lung carcinoma cells and is selected from the group consisting of 1p, 16p, 17p, and 22q or a probe which binds selectively to a target polynucleotide sequence on a chromosomal region which is amplified in non-small cell lung carcinoma cells and is selected from the group consisting or 3q, 5p, and 8q;
- wherein the probe is contacted with the sample under conditions in which the probe binds selectively with the target polynucleotide sequence to form a hybridization complex;
- and
- detecting the formation of a hybridization complex.
1 more element
Dependencies are inferred from the claim text.