Pharamaceutical formulation

A pharmaceutical formulation, being a unit dose sachet comprising granules of granular product containing amoxicillin trihydrate or ampicillin of 5% to 50% by weight and an effervescent couple which couple comprises a physiologically acceptable alkaline or alkaline earth metal carbonate as a basic ingredient and an acidic ingredient selected from the group consisting of citric acid, sodium hydrogen citrate, tartaric, adipic, fumaric and malic acid, the basic ingredient liberating carbon dioxide when it and the acidic ingredient are contacted with water, wherein the basic ingredient is present in 0.5% to 30% of the weight of the formulation and the acid ingredient is present in 0.5% to 20% of the weight of the formulation;

• and further wherein each granule contains both components of the effervescent couple and the amoxicillin trihydrate or ampicillin antibiotic.