Nitroglycerin-containing patch, a process for the production and the use thereof
AssigneeLTS Lohmann Therapie-Systeme BmgH & Co., KG
InventorsReinhold Meconi, Tina Rademacher
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Abstract
An active substance-containing patch for the controlled release of nitroglycerin to the skin, consisting of an impermeable backing layer, a reservoir attached thereto and comprising pressure-sensitive hot melt adhesive and active substance, and a removable protective layer, in which patch the reservoir comprises in homogeneous mixture: a) tackifying soft and/or hard resins, b) plasticizers, c) nitroglycerin preparation.
Claims15
In an active substance-containing patch for the controlled release of nitroglycerin to the skin, consisting of an impermeable backing layer, a reservoir bonded thereto and comprising pressure-sensitive hot melt adhesive and active substance, and a removable protective layer, the improvement wherein the reservoir consists essentially of a solvent-free homogenized mixture of:
- (a) a member selected from the group consisting of (1) a tackifying resin which is semisolid or liquid at room temperature or melts at a temperature up to about 60.degree. C., (2) a tackifying resin which is solid at room temperature and softens at a temperature from about 60.degree. C., and (3) mixtures thereof,
- (b) a plasticizer, and
- (c) a nitroglycerin preparation,
- said mixture being free of other polymers.
A process for the production of an active substance-containing patch for the controlled release of nitroglycerin to the skin which consists essentially of
- (a) homogenizing, in a melt by kneading at elevated temperature without the use of solvents, a member selected from the group consisting of (1) a tackifying resin which is semisolid or liquid at room temperature or melts at a temperature up to about 60.degree. C. (2) a tackifying resin which is solid at room temperature and softens at a temperature from about 60.degree. C., and (3) mixtures thereof;
- (b) cooling the melt, adding a nitroglycerin preparation thereto and homogenizing by further kneading,
- (c) coating the thus-obtained active substance-containing reservoir mass onto a removable protective layer at a constant low temperature and laminating an impermeable backing layer thereon, and
- (d) punching out patches from the thus obtained laminate.
Dependencies are inferred from the claim text.