Long acting GI and esophageal protectant
AssigneeKV Pharmaceuticals Company
InventorsRobert C. Cuca, Keith S. Lienhop, Thomas Charles Riley, Jr., Mitchell I. Kirschner, R. Saul Levinson
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Abstract
A bioadherent, orally ingestible system, which comprises: a water-in-oil emulsion system having at least two phases, one phase comprises from about 75% to about 99% by volume of an internal hydrophylic phase and the other phase comprises from about 25% to about 1% by volume of an external hydrophobic phase, wherein the external hydrophobic phase comprises two components, one component being about 3% to about 97% by volume of the hydrophobic phase of a hydrophobic oil and the other being about 97% to about 3% of an emulsifier having a HLB value less than about 10.
Claims23
A bioadherent, orally ingestible system, which comprises:
- a water-in-oil system having at least two phases, one phase comprises from about 75 to about 99% by volume of an internal hydrophylic phase and the other phase comprises from about 25% to about 1% by volume of an external hydrophobic phase, wherein the external hydrophobic phase is comprised of two components, one component being about 3 to about 97% of a hydrophobic oil the other being about 97% to about 3% of an emulsifier having a HLB value less than 10 wherein the ingestible system adheres to oral mucosa and esophageal mucosa for 30 minutes to 24 hours.
A method for treating an oral, esophageal or GI tract disorder, which comprises:
- administering orally a therapeutically effective amount of a bioadherent, orally ingestible system, which comprises:
- a water-in-oil system having at least two phases, one phase comprises from about 75% to about 99% by volume of an internal hydrophylic phase and the other phase comprises from about 25% to about 1% by volume of an external hydrophobic phase, and wherein the external hydrophobic phase comprises two components, one component being about 3% to about 97% by volume of the hydrophobic phase of a hydrophobic oil and the other being about 97% to about 3% of an emulsifier having a HLB value less than 10 wherein the ingestible system adheres to oral mucosa and esophageal mucosa for 30 minutes to 24 hours.
Dependencies are inferred from the claim text.