Immunoreactive polypeptide compositions
AssigneeChiron Corporation
InventorsAmy J. Weiner, Michael Houghton
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Abstract
This invention relates generally to immunoreactive polypeptide compositions comprising hepatitis type C viral epitopes, methods of using the compositions in immunological applications, and materials and methods for making the compositions.
Claims11
A method for preparing an immunogenic composition for treatment of HCV comprising:
- (a) forming an immunogenic polypeptide composition comprising at least two HCV amino acid sequences, each HCV sequence comprising at least one epitope within a variable domain of an HCV envelope protein, wherein the variable domain regions of the amino acid sequences are heterogeneous with each other, are derived from distinct HCV isolates, and each sequence being not longer than the full length envelope protein, wherein the immunogenic polypeptide composition is suitable for treating HCV;
- (b) providing a suitable excipient;
- and
- (c) mixing the immunogenic composition of (a) with the excipient of (b).
A method of producing anti-HCV antibodies comprising administering to a mammal an effective amount of an immunogenic polypeptide composition comprising at least two HCV amino acid sequences, each HCV sequence comprising at least one epitope within a variable domain of an HCV envelope protein, wherein the variable domain regions of the amino acid sequences are heterogeneous with each other, are derived from distinct HCV isolates, and each sequence being not longer than the full length envelope protein.
Dependencies are inferred from the claim text.