Method for controlling hyperproliferative diseases
AssigneeChiron Corporation
InventorsJames W. Larrick, L. L. Houston, Eric S. Groves
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Abstract
A method for controlling the overgrowth of hyperproliferating cells in the presence of non-proliferating cells by exposing the hyperproliferating cells to a toxin conjugate that has a binding region that binds to an internalizable element of the hyperproliferating cell and a toxic moiety bound thereto is provided. The toxin conjugate may be a monoclonal antibody to transferrin receptor. Such toxin conjugates will have use in controlling hyperproliferative diseases of the integument and the eye.
Claims10
A method of treating a nonmalignant hyperproliferating ocular epithelial or endothelial cell condition comprising exposing said hyperproliferating cells to a concentration of toxin conjugate sufficient to kill the hyperproliferating cells, wherein said toxin conjugate comprises:
- (a) an antigen binding portion of an antibody capable of binding to a transferrin growth factor receptor without competing with binding of transferrin to the transferrin growth factor receptor;
- and (b) a plant toxin molecule.
A method of treating a patient in need of treatment of a nonmalignant hyperproliferating ocular epithelial or endothelial cell condition, the method comprising administering to said patient an amount of a toxin conjugate sufficient to kill said hyperproliferating cells, wherein said toxin conjugate comprises:
- (a) an antigen binding portion of an antibody capable of binding to a transferrin growth factor receptor without competing with binding of transferrin to the transferrin growth factor receptor;
- and (b) a plant toxin molecule.
Dependencies are inferred from the claim text.