2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging
AssigneeNahoSystems L.L.C.
InventorsEdward R. Bacon, Sol J. Daum, Kimberly G. Estep
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Abstract
Compounds having the structure: ##STR1## wherein Q is ##STR2## n is an integer from 0 to 20; R.sup.1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido; R.sup.6 is alkyl, cycloalkyl, aryl, or aralkyl; and R.sup.7 is H or --COR.sup.6 are useful as contrast agents in medical diagnostic x-ray imaging compositions and methods.
Claims7
A method of imaging a mammal's blood pool and lymph nodes, the method comprising
- (a) administering to the mammal a contrast enhancing effective amount of the x-ray contrast composition, the composition comprised of 1-99.9% by weight of nanoparticles of a compound having the structure ##STR12## ##STR13## wherein Q is n is an integer from 0 to 4;
- R.sup.1 is alkyl;
- R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently H or alkyl;
- R.sup.6 is alkyl;
- and
- R.sup.7 is H;
- and
- b) imaging the mammal's blood pool and lymph nodes.
Dependencies are inferred from the claim text.