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US 5,669,396 AGranted
Methods of detecting and treating vaso-occlusive crisis in sickle cell disease
AssigneePresident and Fellows of Harvard College
InventorsDavid Eric Golan, Hemant Sadashiv Thatte, Alexandru Cristian Bageac
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Abstract
Methods are described for treating sickle cell disease, and in particular, detection and treatment of vaso-occlusive crisis in sickle cell disease. Antibodies are employed which bind competitively and suppress adhesion of sickle erythrocytes to autologous lymphocytes.
Claims17
A method of testing blood, comprising:
- a) providing blood from a patient with sickle cell disease;
- and
- b) examining said blood to determined the incidence of preformed lymphocyte/erythrocyte conjugates as a test for sickle cell crisis.
A method of testing blood, comprising:
- a) providing i) erythrocytes from a patient with sickle cell disease;
- and ii) autologous lymphocytes from said patient with sickle cell disease;
- b) mixing said autologous lymphocytes and said erythrocytes in vitro to create a cell suspension under conditions such that lymphocyte/erythrocyte conjugates can form;
- and
- c) determining the incidence of lymphocyte/erythrocyte conjugates as a test for sickle cell crisis.
2 more elements
Dependencies are inferred from the claim text.