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US 5,668,291 AGranted
Arylthio compounds
AssigneeWarner-Lambert Company
InventorsJohn Michael Domagala, Edward Faith Elslager, Rocco Dean Gogliotti
Life of this patent
Estimating the term…
Abstract
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N, R.sup.1 and R.sup.2 are substituent groups, X is ##STR2## or SO.sub.2 NR.sup.4 Z, Y is H or SZ when n is 1, a single bond when n is 2; R.sup.4 and Z can be hydrogen or alkyl.
Claims11
A compound of the formula ##STR46## wherein:
- n is 1 or 2;
- X is ##STR47## or SO.sub.2 NR.sup.4 Z;
- Y is hydrogen or SZ when n is 1, and is a single bond when n is 2;
- Z is hydrogen, halo, C.sub.1 -C.sub.6 alkyl, COC.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl-(CR.sup.5 R.sup.6).sub.m --, phenyl-(CR.sup.5 R.sup.6).sub.m, or Het--(CR.sup.5 R.sup.6).sub.m --;
- R.sup.1 and R.sup.2 independently are hydrogen, halo, C.sub.1 -C.sub.6 alkyl, O--C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, hydroxy, cyano, phenyl-(CR.sup.5 R.sup.6).sub.m --, Het--(CR.sup.5 R.sup.6).sub.m, NR.sup.3 R.sup.4, NR.sup.3 COR.sup.4, CO.sub.2 R.sup.3, CONR.sup.3 R.sup.4, S(O).sub.m R.sup.3, S(O).sub.m NR.sup.3 R.sup.4, COR.sup.3, or taken together are oxo (O.dbd.) or methylene dioxy (--O--CH.sub.2 --O);
- m is 0, 1, or 2;
- R.sup.3 and R.sup.4 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, phenyl-(CR.sup.5 R.sup.6).sub.m --, Het--(CR.sup.5 R.sup.6).sub.m --;
- R.sup.5 and R.sup.6 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, hydroxy, COOH, amino, or cyano;
- wherein the foregoing alkyl, cycloalkyl, phenyl, and Het groups may optionally be substituted with from 1 to 3 groups selected from halo, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, hydroxy, cyano, nitro, NR.sup.3 R.sup.4, NR.sup.3 COR.sup.4, CO.sub.2 R.sup.3, ##STR48## CONR.sup.3 R.sup.4, PO.sub.4 (R.sup.3).sub.3, S(O).sub.m NR.sup.3 R.sup.4, and COR.sup.3, where m, R.sup.3, and R.sup.4 are as defined above;
- and the pharmaceutically acceptable salts and solvates thereof.
7 more elements
Dependencies are inferred from the claim text.