Pyridinone thrombin inhibitors

A compound having the formula:

• ##STR63## wherein W is
• R.sup.1,
• R.sup.1 OCO,
• R.sup.1 CO,
• R.sup.1 SO.sub.2,
• (R.sup.1).sub.m (CH.sub.2).sub.n NHqCO,
• where n is 0-4, m is 1 or 2, and q is 0 or 1, with the proviso that where n is 1-4, q is 1 and m is 1, and where n is 0, m is 1 or 2, and q is 0 or 1, and where n is 0, m is 2 and q is 0, R.sup.1 can be the same or different;
• R.sup.1 is
• R.sup.2 (CH.sub.2).sub.n, where n is 0-4,
• (R.sup.2)(OR.sup.2)CH(CH.sub.2).sub.p, where p is 1-4,
• (R.sup.2).sub.2 CH(CH.sub.2).sub.n, where n is 0-4 and R.sup.2 can be the same or different, and wherein (R.sup.2).sub.2 can also be a ring substituent on CH represented by C.sub.3-7 cycloalkyl, C.sub.7-12 bicyclic alkyl, and
• R.sup.2 O(CH.sub.2).sub.p, wherein p is 1-4;
• R.sup.2 is
• hydrogen,
• phenyl, unsubstituted or substituted with one or more of C.sub.1-4 linear or branched alkyl, C.sub.1-4 linear or branched alkoxy, halogen, trifluoromethyl, hydroxy, COOH, or CONH.sub.2,
• naphthyl,
• biphenyl,
• COOR.sup.6,
• C.sub.1-4 linear or branched alkyl, C.sub.3-7 cycloalkyl, or
• C.sub.7-12 bicyclic alkyl;
• R.sup.3 is
• hydrogen,
• C.sub.1-4 linear or branched alkyl,
• C.sub.3-7 cycloalkyl, or
• trifluoromethyl;
• A is chosen from one of the following Radicals:
• ##STR64## wherein R.sup.4 and R.sup.5 are independently H, C.sub.1-4 linear or branched alkyl or alkoxy;
• C.sub.3 -C.sub.7 cycloalkyl;
• halogen;
• or trifluoromethyl;
• Y is
• hydrogen,
• hydroxy, or
• CN;
• R.sup.6 is
• hydrogen, or
• C.sub.1-4 linear or branched alkyl,
• and pharmaceutically acceptable salts thereof.