Polyester ionomers for implant fabrication
AssigneeDePuy Orthopaedics, Inc.
InventorsRobson F. Storey, Z. David Deng, Todd P. Glancy, Dale R. Peterson
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Abstract
Carboxy-terminated polyester ionomers useful for bioresorbable implant construction are described. They comprise biocompatible salts or partial salts of mono- or bis-carboxy-terminated polyesters.
Claims20
A non-toxic salt of a biodegradable carboxy-terminated polyester of the general formula RO.about.PE.about.COOH or HOOC.about.PE.about.COOH wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl and .about.PE.about. is a divalent residue of a polyester comprising a homopolymer, copolymer or terpolymer of biocompatible hydroxy acids or a copolymer of biocompatible dihydric alcohols and biocompatible dicarboxylic acids.
A composition of matter comprising a biodegradable carboxy-terminated polyester of the general formula RO.about.PE.about.COOH and a non-toxic salt thereof wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl and .about.PE.about. is a divalent residue of a polyester comprising a homopolymer, copolymer or terpolymer of biocompatible hydroxy acids or a copolymer of biocompatible dihydric alcohols and biocompatible dicarboxylic acids.
A composition of matter comprising a biodegradable, carboxy-terminated polyester of the general formula HOOC.about.PE.about.COOH and a non-toxic salt thereof wherein .about.PE.about. is a divalent residue of a polyester comprising a homopolymer, copolymer or terpolymer of biocompatible hydroxy acids or a copolymer of biocompatible dihydric alcohols and biocompatible dicarboxylic acids.
An improved matrix composition for tissue repair, said matrix composition comprising a bioerodable synthetic polymer and optionally a filler and/or a biologically active compound, wherein synthetic polymer comprises a non-toxic polyester salt of a biodegradable carboxy-terminated polyester of the general formula RO.about.PE.about.COOH or HOOC.about.PE.about.COOH wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl and .about.PE.about. is a divalent residue of a polyester comprising a homopolymer, copolymer or terpolymer of biocompatible hydroxy acids or a copolymer of biocompatible di- or trihydric alcohols and biocompatible dicarboxylic acids.
Dependencies are inferred from the claim text.