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US 5,668,265 AGranted
Bi-directional oligonucleotides that bind thrombin
AssigneeBecton, Dickinson and Company
InventorsJames G. Nadeau, Mary Lee Ciolkowski, Erwin A. Vogler
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Abstract
The present invention relates to bi-directional nucleic acid ligand compounds wherein at least two oligonucleotides of opposite sequence polarity are linked to a connecting compound at their same respective terminii; either the 5' terminii or the 3 ' terminii. These compounds are useful for binding protein or small molecule targets and thus may be used as diagnostic or therapeutic agents.
Claims17
A bi-directionai nucleic acid ligand compound comprising at least two oligodeoxyribonucleotides each independently selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:2 and SEQ ID NO:3, wherein the two oligodeoxyribonucleotides are linked either directly or by a connecting compound in a 5' to 5' or a 3' to 3' orientation.
Dependencies are inferred from the claim text.