Conserved yeast nucleic acid sequences
AssigneeSmithKline Beecham Corporation
InventorsLois L. Hoyer, George P. Livi, Allan R. Shatzman
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Abstract
This invention relates to nucleic acid sequences conserved in strains of yeasts. More particularly, this invention relates to segments of the ALSl gene of Candida albicans useful as probes and primers for the identification of yeast, particularly Candida, infections.
Claims5
An isolated DNA consisting of a sequence selected from the group of sequences given herein as SEQ. ID. NO:1, SEQ. ID. NO:2, SEQ. ID. NO:3, SEQ. ID. NO:4 and SEQ. ID. NO:5.
A nucleic acid probe capable of selectively hybridizing to C. albicans and C. stellatoidea nucleic acids, said probe consisting of a sequence selected from the group of sequences given herein as SEQ. ID. NO:1, SEQ. ID. NO:2, SEQ. ID. NO:3, SEQ. ID. NO:4 and SEQ. ID. NO:5. and fragments thereof which are capable of selectively hybridizing with C. albicans and C. Stellatoidea nucleic acids.
Amplification primer pairs consisting of the sequences given herein as SEQ. ID. NO:3 as a 5' primer and SEQ. ID. NO:4 as a 3' primer and fragments thereof which are capable of selectively amplifying C. albicans and C. Stellatoidea nucleic acids.
A set of amplification primer pairs consisting of one or more of the 5' primer sequences represented by SEQ. ID. NO:3 and one or more of the 3' primer sequences represented by SEQ. ID. NO:4 and fragments thereof which are capable of selectively amplifying C. albicans and C. Stellatoidea nucleic acids.
Dependencies are inferred from the claim text.