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US 5,668,256 AGranted
Chimeric interleukin 5-receptor/immunoglobulin polypeptides
AssigneeHoffmann-La Roche Inc.
InventorsRene Devos, Walter Fiers, Jose van der Heyden, Geert Plaetinck, Jan Tavernier
Life of this patent
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Abstract
Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.
Claims1
A recombinant polypeptide coded for by a DNA sequence, which DNA sequence comprises:
- a) a first DNA subsequence encoding a soluble fragment of human interleukin-5 receptor alpha chain capable of binding human interleukin-5, and
- b) a second DNA subsequence encoding a constant domain of a human immunoglobulin heavy chain or light chain.
Dependencies are inferred from the claim text.