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US 5,668,178 AGranted
Arylthio compounds
AssigneeWarner-Lambert Company
InventorsEdward Faith Elslager, Rocco Dean Gogliotti
Life of this patent
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Abstract
Phenylthiols and dithiobisbenzamides are potent antibacterial and antiviral agents.
Claims5
A method of treating retroviral infections comprising administering to a subject in need of treatment an antivirally effective amount of a compound of the formula ##STR12## wherein:
- R.sup.1 and R.sup.11 independently are hydrogen, halo, C.sub.1 -C.sub.6 alkyl, hydroxy, C.sub.1 -C.sub.6 alkoxy, carboxy, C.sub.1 -C.sub.6 alkoxycarbonyl, or NR.sup.2 R.sup.3, where R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sup.3 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkanoyl;
- R.sup.4 is hydrogen or C.sub.1 -C.sub.6 alkyl;
- Z is C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl, where said alkyl and cycloalkyl groups may have 1 or 2 substituents selected from hydroxy, halo, nitro, NR.sup.2 R.sup.3, carboxy, and C.sub.1 -C.sub.6 alkoxycarbonyl;
- or
- Z is ##STR13## where and as defined above;
- and pharmaceutically acceptable salts and solvates thereof.
3 more elements
Dependencies are inferred from the claim text.