Composition and method enhancing transdermal electrotransport agent delivery
AssigneeAlza Corporation
InventorJ. Richard Gyory
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Abstract
A composition comprises an agent to be delivered through a body surface and an electrotransport enhancer having a hydrophobic tail and a polar head of specific characteristics. An electrotransport delivery device is also provided having a reservoir comprising the agent to be delivered and the electrotransport enhancer of the invention. The electrotransport enhancers increase the electrotransport delivery rate of the agent through the surface while reducing the electrical resistance of the surface during electrotransport of the agent.
Claims16
A composition for the transdermal electrotransport delivery of an agent comprising:
- a) at least one agent for transdermal delivery;
- and
- b) at least one transdermal electrotransport enhancer having a hydrophile-lipophile balance (HLB) number greater than about 6 and comprising a hydrophobic tail and a polar head of less than about 150 Dalton MW, the polar head group being uncharged or having a charge opposite the charge of the agent to be delivered if the agent is ionizable in solution;
- wherein the electrotransport enhancer is selected from the group consisting of saturated C.sub.10 -C.sub.12 aliphatic alcohols, amines, mono- and di-substituted amines, quaternary ammonium salts, sulfoxides, sulfates, amides, mono- and di-substituted amides, esters and salts thereof.
A method of electrotransport delivery of an agent through a body surface comprising contacting the body surface with a composition comprising at least one agent to be delivered and at least one transdermal electrotransport enhancer and applying an electrical current therethrough, wherein the enhancer has a hydrophile-lipophile balance (HLB) number greater than about 6, a hydrophobic saturated C.sub.10 -C.sub.12 aliphatic chain tail and a polar head group of less than about 150 Dalton MW, the polar head group being uncharged or having a charge opposite the charge of the agent to be delivered if the agent is ionizable in solution;
- the electrotransport enhancer being selected from the group consisting of saturated C.sub.10 -C.sub.12 aliphatic alcohols, amines, mono and di-substituted amines, quaternary ammonium salts, sulfoxides, sulfates, amides, mono- and di-substituted amides, esters and salts thereof.
Dependencies are inferred from the claim text.