Isothiazolones lower plasma levels of lipoprotein(a)

A method for lowering plasma Lp(a) levels in a mammal comprising administering an Lp(a) lowering amount of a compound of Formula I ##STR117## wherein:

• A is a monocyclic ring having 5 or 6 ring atoms, or a bicyclic ring having from 9 to 12 ring atoms, the ring atoms being selected from carbon and optionally up to 3 heteroatoms selected from O, S, and N;
• R.sup.1 and R.sup.2 independently are hydrogen, halo, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, Het(CR.sup.6 R.sup.7).sub.m -, phenyl-(CR.sup.6 R.sup.7).sub.m -, O-C.sub.1 -C.sub.6 alkyl, hydroxy, nitro, cyano, NR.sup.3 R.sup.4, NR.sup.3 COR.sup.4, CO.sub.2 R.sup.3, CONR.sup.3 R.sup.4, S(O).sub.m R.sup.3, SO.sub.3 H, S(O).sub.m NR.sup.3 R.sup.4, COR.sup.3, or taken together are oxo (O.dbd.) or methylene dioxy (-O-CH.sub.2 -O-);
• m is 0, 1, or 2;
• R.sup.3 and R.sup.4 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, Het(CR.sup.6 R.sup.7).sub.m -, or phenyl-(CR.sup.6 R.sup.7).sub.m -;
• R.sup.6 and R.sup.7 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, CO.sub.2 R.sup.3, hydroxy, CONR.sup.3 R.sup.4, or cyano;
• R.sup.5 is hydrogen, C.sub.1 -C.sub.6 alkyl, COC.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, phenyl-(CR.sup.6 R.sup.7).sub.m - , Het(CR.sup.6 R.sup.7).sub.m -;
• and
• wherein the foregoing alkyl, cycloalkyl, phenyl, and Het groups may optionally be substituted with from 1 to 3 groups selected from halo, hydroxy, nitro, NR.sup.3 R.sup.4, NR.sup.3 COR.sup.4, CO.sub.2 R.sup.3, CONR.sup.3 R.sup.4, S(O).sub.m R.sup.3, S(O).sub.m NR.sup.3 R.sup.4, and COR.sup.3, where m, R.sup.3, and R.sup.4 are as defined above;
• and the pharmaceutically acceptable salts and solvates thereof.