1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists

A compound of the formula ##STR86## or a pharmaceutically acceptable salt thereof wherein:

• R.sup.1 is selected from R.sup.2 HN--, R.sup.2 HN(R.sup.2 N.dbd.)C--, R.sup.2 HN(CH.sub.2).sub.q Z--, R.sup.2 HN(R.sup.2 N.dbd.)C(CH.sub.2).sub.q Z--, R.sup.2 HN(R.sup.2 N.dbd.)CN(R.sup.2)--, R.sup.2 HNC(O)--, R.sup.2 (R.sup.5 O)N(R.sup.2 N.dbd.)C--, or R.sup.2 HN(R.sup.5 ON.dbd.)C--;
• alternatively, R.sup.1 is H when Ar is -(piperidinyl)-;
• q is 1-3;
• Z is selected from a bond (i.e. is absent), O, S, or S(.dbd.O), S(.dbd.O).sub.2 ;
• R.sup.2 is selected from H, aryl (C.sub.1 -C.sub.10 alkoxy)carbonyl, or C.sub.1 -C.sub.10 alkoxycarbonyl, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 alkenyl;
• R.sup.5 is selected from H or C.sub.1 -C.sub.10 alkyl substituted with 0-1 R.sup.4b ;
• R.sup.4b is selected from C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.7 -C.sub.14 bicycloalkyl, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylsulfinyl, C.sub.1 -C.sub.6 alkylsulfonyl, nitro, C.sub.1 -C.sub.6 alkylcarbonyl, C.sub.6 -C.sub.10 aryl, --N(R.sup.12)R.sup.13 ;
• halo, CF.sub.3, CN, C.sub.1 -C.sub.6 alkoxycarbonyl, carboxy, piperidinyl, morpholinyl or pyridinyl;
• Ar is selected from:
• -(piperidinyl)- substituted with 0-2 R.sup.6a,
• -(phenyl)- substituted with 0-2 R.sup.6a, or
• -(pyridyl)- substituted with 0-2 R.sup.6a ;
• R.sup.6a is selected from C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, NO.sub.2, or NR.sup.12 R.sup.13 ;
• A is selected from O or S;
• W is selected from --(CH.sub.2).sub.n -- or --S(CH.sub.2).sub.n-1 --;
• X is selected from --C(CH.sub.2 --Ph)H--, --CH.sub.2 --, --CH.sub.2 C(NHR.sup.12)H-- or --C(CH.sub.2 NHR.sup.12)H--;
• Y is selected from hydroxy, C.sub.1 to C.sub.10 alkyloxy, C.sub.3 to C.sub.11 cycloalkyloxy, C.sub.6 to C.sub.10 aryloxy, C.sub.7 to C.sub.11 aralkyloxy, C.sub.3 to C.sub.10 alkylcarbonyloxyalkyloxy, C.sub.3 to C.sub.10 alkoxycarbonyloxyalkyloxy, C.sub.2 to C.sub.10 alkoxycarbonylalkyloxy, C.sub.5 to C.sub.10 cycloalkylcarbonyloxyalkyloxy, C.sub.5 to C.sub.10 cycloalkoxycarbonyloxyalkyloxy, C.sub.5 to C.sub.10 cycloalkoxycarbonylalkyloxy, C.sub.7 to C.sub.11 aryloxycarbonylalkyloxy, C.sub.8 to C.sub.12 aryloxycarbonyloxyalkyloxy, C.sub.8 to C.sub.12 arylcarbonyloxyalkyloxy, C.sub.5 to C.sub.10 alkoxyalkylcarbonyloxyalkyloxy, C.sub.5 to C.sub.10 (5-alkyl-1,3-dioxa-cyclopenten-2-one-yl)methyloxy, C.sub.10 to C.sub.14 (5-aryl-1,3-dioxa-cyclopenten-2-one-yl)methyloxy, (R.sup.2)HN--(C.sub.1 -C.sub.10 alkoxy)--;
• m is 0-2;
• n is 1-4;
• and
• R.sup.12 and R.sup.13 are each independently selected from H;
• C.sub.1 -C.sub.10 alkyl;
• C.sub.1 -C.sub.10 alkoxycarbonyl;
• C.sub.1 -C.sub.10 alkylcarbonyl;
• C.sub.1 -C.sub.10 alkylsulfonyl;
• aryl, aryl(C.sub.1 -C.sub.10 alkyl)sulfonyl, and arylsulfonyl wherein said aryls and heteroaryls are substituted with 0-3 substituents selected from the group consisting of:
• C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, and NO.sub.2 ;
• and heteroaryl(C.sub.1 -C.sub.4 alkyl)sulfonyl, heteroarylcarbonyl, heteroarylsulfonyl, and heteroarylalkylcarbonyl wherein said heteroaryls are substituted with 0-3 substituents selected from the group consisting of:
• C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, and NO.sub.2 ;
• provided that m and n are chosen such that the number of atoms connecting R.sup.1 and y is in the range of 10-18.