Inhibition of human immunodeficiency virus-1 infectivity in human cells
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsStephen Oroszlan, Wen-Po Tsai, Peter L. Nara, Hsiang-Fu Kung
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Abstract
Methods are disclosed for inhibiting the infectivity of HIV-1 in human cells. The methods comprise contacting human cells infected with HIV-1, with certain quinolinyl and acridinyl derivatives, including amodiaquin, chloroquine, hydroxychloroquine, primoquine, quinacrine and compounds having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, or join to form a cyclic structure of the formula: ##STR2## and R.sup.3 and R.sup.4, same or different, are hydrogen, C.sub.1 -C.sub.8 lower alkyl or hydroxy substituted C.sub.1 -C.sub.8 lower alkyl, and the pharmaceutically acceptable salts thereof.
Claims4
A method of inhibiting HIV-1 infectivity in chronically infected human cells, the method comprising:
- contacting HIV-1 infected human cells with an effective HIV-1 replication inhibiting amount of chloroquine or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.