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US 5,668,142 AGranted
Tetracyclic piperidine and 1,4-oxazine compounds
AssigneeAdir et Compagnie
InventorsJean-Louis Peglion, Joel Vian, Bertrand Goument, Mark Millan, Valerie Audinot, Jean-Charles Schwartz, Pierre Sokoloff
Life of this patent
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Abstract
New compounds of formula: ##STR1## wherein A-B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.
Claims4
A compound selected from those of formula I ##STR38## wherein:
- X represents an oxygen atom or CH.sub.2, and Y represents CH.sub.2
- A-B represents --(CH.sub.2).sub.2 -- or --HC.dbd.CH-- or ##STR39## R represents a hydrogen atom or a (C.sub.1 -C.sub.10)alkyl, (C.sub.3 -C.sub.10)alkenyl, or (C.sub.3 -C.sub.10)alkynyl radical, each of which may be in straight or branched chain and each of which may optionally be substituted by a cycloalkyl radical having 3 to 8 carbon atoms, or by an aryl radical selected from the radicals phenyl, thienyl and pyridyl, each of which may optionally be substituted by one or more substituents selected from halogen atoms, hydroxy radicals, and alkyl and alkoxy radicals each having 1 to 6 carbon atoms in straight or in branched chain;
- and
- n represents:
- 0or 1 when X represents CH.sub.2 and
- 1 only, when X represents an oxygen atom
- their geometric isomer forms, cis and trans,--their racemic mixture or racemate, and their optical isomer or enantiomer forms,
- and their salts with a pharmaceutically-acceptable acid.
5 more elements
Dependencies are inferred from the claim text.