A1 adenosine receptor agonists and antagonists
AssigneeUniversity of Flordia Research Foundation, Inc.
InventorsLuiz Belardinelli, Ray Olsson, Stephen Baker, Peter J. Scammells, Peter G. Milner, Jurg R. Pfister, George F. Schreiner
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Abstract
Adenosine and xanthine derivatives, and compositions comprising those compounds, are potent selective agonists and antagonists of adenosine receptors. The derivatives and compositions are used to treat conditions, including certain cardiac arrhythmias.
Claims7
A method for protecting renal tissue from damage by a nephrotoxic agent, said method comprising administering to a patient an effective amount of a compound having a structure selected from the group consisting of ##STR6## wherein R.sub.1 and R.sub.2 are the same or different, and can be H or an alkyl group of 1-4 carbons, and n=0-4;
- and ##STR7## wherein R.sub.1 and R.sub.2 are the same or different, and can be H or an alkyl group of 1-4 carbons, R.sub.3 is either O or (CH.sub.2).sub.1-4, and n=0-4.
Dependencies are inferred from the claim text.