N-substituted azaheterocyclic carboxylic acids and esters thereof
AssigneeNovo Nordisk A/S
InventorsKnud Erik Andersen, Uffe Bang Olsen, Hans Petersen, Frederik Christian Gr.o slashed.nvald, Ursula Sonnewald, Tine Krogh J.o slashed.rgensen, Henrik Sune Andersen
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Abstract
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
Claims15
A compound of formula I ##STR3## wherein R.sup.1 and R.sup.2 independently are hydrogen, halogen, trifluoromethyl, C.sub.1-6 -alkyl or C.sub.1-6 -alkoxy;
- Y is >
- N--CH.sub.2 --, wherein only the underscored atom participates in the ring system;
- X is --CH.dbd.CH--CH.sub.2 --, --CH.sub.2 --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 CH.sub.2 --;
- r is 1, 2, or 3;
- m is 1 or 2;
- n is 1 when m is 1 and n is 0 when m is 2;
- R.sup.4 and R.sup.5 are hydrogen when m is 1;
- R.sup.4 and R.sup.5 are hydrogen or form a bond when m is 2;
- and
- R.sup.6 is OH or C.sub.1-8 -alkoxy;
- or
- a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.