Aziridine derivatives, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsShigetoshi Tsubotani, Masayuki Takizawa, Mikio Shirasaki, Junji Mizoguchi, Yoshiaki Shimizu
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Abstract
The present invention relates to a compound of the formula: ##STR1## wherein R.sub.1 and Q are independently an optionally esterified or amidated carboxyl group; R.sub.2 is hydrogen, an acyl group or an optionally substituted hydrocarbon residue; X is a divalent hydrocarbon residue which may be substituted; or a salt thereof, which is useful as prophylactic and therapeutic agents of bone diseases and as agents for inhibiting thiol protease.
Claims37
A compound of the formula:
- ##STR10## wherein R.sub.1 and Q are independently a carboxyl group which may be esterified or amidated;
- R.sub.2 is hydrogen, an acyl group or a C.sub.1-20 hydrocarbon residue;
- and
- X is a C.sub.1-20 divalent hydrocarbon residue;
- or a salt thereof.
N-(N-((2S,3S)-3-ethoxycarbonylaziridine -2-carbonyl)-L-phenylalanyl)-2-phenylethylamine.
N-(N-((2S,3S)-3-ethoxycarbonylaziridine-2-ca rbonyl)-L-phenylalanyl)isopentylamine.
N-(N-((2S,3S)-3-ethoxycarbonylazir idine-2-carbonyl)-L-phenylalanyl)-3-methoxypropylamine.
N-(N-((2S,3S)-3-ethoxycarbonylaziridine-2-carbonyl) -L-phenylalanyl)-N-methyl-2-phenylethylamine.
Dependencies are inferred from the claim text.