Glutamate (NMDA) receptor antagonists
AssigneeWarner-Lambert Company
InventorsChristopher Franklin Bigge, James Jia-He Li
Life of this patent
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Abstract
Novel naphthyl-substituted .alpha.-amino acid derivatives, pharmaceutical compositions containing the same and a method of using the same, for the blockade of aspartate and glutamate receptors, are described. Novel intermediates of the napthyl-substituted .alpha.-amino acid derivatives are disclosed.
Claims14
A compound represented by the formula:
- ##STR28## or a pharmaceutically acceptable acid addition, or base salt thereof wherein (a) m and n are independently an integer of 0 to 3;
- (b) R, R.sup.2 and R.sup.3 are independently hydrogen or a pharmaceutically acceptable labile ester or amide residue;
- (c) R.sup.1 is hydrogen or a protective group;
- and (d) X, Y and Z are independently hydrogen, halogen, amino, hydroxy, hydroxyalkyl having 1 to 6 carbon atoms, haloalkyl having 1 to 6 carbon atoms, cyano, nitro, alkyl having 1 to 6 carbon atoms, cycloalkyl, aryl, aralkyl, aminoalkyl having 1 to 6 carbon atoms or alkoxy having 1 to 6 carbon atoms.
A method for treating anxiety which comprises administering in unit dosage form at least one compound selected from the group consisting of 3-(1-naphthalenyl)-5-(phosphonomethyl)-DL-phenylalanine and 3-(1-naphthalenyl)-5-(phosphonomethyl)-L-phenylalanine.
A method for treating cerebral hypoxic/ischemia which comprises administering in unit dosage form at least one compound selected from the group consisting of 3-(1-naphthalenyl)-5-(phosphonomethyl)-DL-phenylalanine and 3-(1-naphthalenyl)-5-(phosphonomethyl)-L-phenylalanine.
A method for treating Parkinsonism which comprises administering in unit dosage form at least one compound selected from the group consisting of 3-(1-naphthalenyl)-5-(phosphonomethyl)-DL-phenylalanine and 3-(1-naphthalenyl)-5-(phosphonomethyl)-L-phenylalanine.
Dependencies are inferred from the claim text.